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Asked by karen1972 - 6 years ago
in the lumbar area of the spinal cord
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smohpal Level 22 / ENGINEER
Answered 6 years ago
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We examined the impact of degenerative conditions in the spine (osteophytosis and endplate sclerosis) and aortic calcification in the lumbar region on bone mineral content/density (BMC/BMD) measured in the spine and forearm by absorptiometry and on fracture risk prediction. The radiographs of 387 healthy postmenopausal women, aged 68–72 years, were assessed in masked fashion for the presence of osteophytosis, endplate sclerosis and aortic calcification in the region from L2 to L4. Vertebral deformities/fractures were assessed by different definitions. Osteophytes larger than 3 mm and in numbers of 3 or more resulted in a significantly (12%) higher spinal bone mass (p<0.001). Endplate sclerosis had a similar effect (p<0.001). In subjects with both degenerative conditions the BMC/BMD in the spine and forearm were significantly higher than in unaffected women (19% in the spine, 10% in the forearm;p<0.001). The spinal BMD values were significantly lower in fractured women if both degenerative conditions were absent (p<0.001), whereas fractured and unfractured women had similar values if degenerative conditions were present. Degenerative conditions did not alter the ability of forearm BMC to discriminate vertebral or peripheral fractures. Receiver operating characteristic (ROC) curves (true positive fraction versus false positive fraction) were generated for BMD of the lumbar spine and BMC of the forearm with regard to the discrimination between women with vertebral and peripheral fractures and healthy premenopausal women. The ROC curves for women without degenerative conditins were consistently above the curves for women affected by osteophytosis and endplate sclerosis in the lumbar spine (p<0.001). In conclusion, osteophytes and endplate sclerosis have a considerable influence on spinal bone mass measurements in elderly postmenopausal women and affect the diagnostic ability of spinal scans to discriminate osteoporotic women. Our data suggest that in elderly women, unless the spine is radiologically clear of degenerative conditions, a peripheral measurement procedure should be considered an alternative for assessment of bone mineral content/ensity.
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Richard Level 76 / Retired Dentist
Answered 6 years ago
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The End Plate. This consists of a narrow zone of hyaline cartilage covering each surface of the vertebral body. The end plate, along with the annulus, is perforated by thousands of small holes through which the tissue fluid diffuses. The fluid diffuses both into and out of the disc.

Sclerosis is a condition where the density is significantly increased.

The lumbosacral spinal cord and nerve supply legs, pelvis, and bowel and bladder. Sensations from the feet, legs, pelvis, and lower abdomen are transmitted through the lumbosacral nerves and spinal cord to higher segments and eventually the brain.
Here is a picture of the spinal chord showing the areas:
http://www.spinalinjury.net/html/_anatom...
explicate Level 12 / Military/Government Work
Answered 6 years ago
1
Endplate sclerosis is a finding that is seen on x-rays of the spine that has been reported in association with degenerative disk disease and herniated disks that are of long standing duration.

http://www.spine-health.com/topics/cd/de...
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