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Asked by jabreha3765 - 5 years ago
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Richard Level 79 / Retired Dentist
Answered 5 years ago
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This depends on whether you are talking about inflammation or pain.
In a double-blind, single-dose study, Seymour and colleagues showed that there is little analgesic advantage to doses of ibuprofen above 400 mg. Higher dosages of
ibuprofen may, however, be beneficial in the treatment of inflammation.

Acetaminophen has a demonstrated analgesic ceiling effect at 1000 mg.
Acetaminophen is effective and safe for mild pain but is often inadequate for more severe pain.
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